Overview of clinical cases profiled by combined DNA/RNA NGS assay. (A) Tumor type distribution of all hematologic tumor cases profiled by the NGS-based DNA/RNA test. (B) Disease ontology distribution of 297 NHL tumors profiled by the assay. PMBCL, primary mediastinal (thymic) large B-cell lymphoma; AITL, angioimmunoblastic T-cell lymphoma. (C) Genomic alterations detected from the 1931 clinical specimens and distribution of alteration types. Top 50 most frequent altered genes are displayed. Red: base substitutions, steel blue: indels, peach: CNAs, lime green: rearrangement. (D) Distribution of alteration types including base substitutions, indels, CNAs, and rearrangements in the clinical specimens.