Combined DNA and RNA sequencing for detection of complex rearrangements. (A) Circos plot showing broad range of fusions in cell line mixes used for validation of fusion calling. (B) Three MLL-PTD isoforms that were tested (from top to bottom): duplication of MLL exons 2 to 8, exons 2 to 10, and exons 4 to 8. (C) Breakpoints on the IGH and its partner genes for the 13 clinical concordance samples including 5 IGH-MYC, 2 IGH-BCL6, 5 IGH-CCND1, and 11 IGH-BCL2 rearrangements.