Forest plot association analysis of the 28 nonsynonymous variants identified in WES and replicated in 227 severe HA patients. TaqMan SNP genotyping-based replication was performed in 53 inhibitor-positive and 174 inhibitor-negative patients. Data analysis was performed using logistic regression analysis adjusting for first-degree relatives. Black diamonds denote OR estimates, and the black bars denote the range of 95% CIs of each variant replicated. Red dots denote OR of variants showing the same trend with WES. Red rectangle denotes statistically significant association, and blue rectangles denote variants with borderline P values. The graph was generated using R.³¹