Pretreatment of both AML blasts and NK effector cells with DAC or 5-azacytidine does not inhibit BI 836858–mediated ADCC or NK-cell activation. Both NK cells from healthy donors and AML blasts were exposed to DAC (500 nM) or 5-azacytidine (2 µM) for 48 hours before AML blasts were coated with BI 836858 or BI 836847 and coincubated for the ADCC assay (10 µg/mL, E:T = 3:1; A) or CD107a assay (5 µg/mL, E:T = 2:1; B). Shown are representative data of NK cells from 2 donors against 2 AML primary blasts. **P < .01, ***P < .001. ns, not significant.