FOXO1 is essential for R406 and the MK2206 synergistic effect in tonic BCR signal-dependent DLBCL cells. (A) Cellular proliferation was assessed in DLBCL cell lines following 72-hour incubation with indicated concentrations of R406 and MK2206 by MTS. (B) DHL4 and Ly7 cells transduced with indicated shRNA vectors were treated and analyzed as described above. For further information please refer to supplemental Tables 9 and 10.