Sequence variations in VWD are most common in subjects with VWF:Ag <30 IU/dL. This graph shows the number of subjects with sequence variations (either point mutations, or insertions or deletions) in the VWF coding sequence (dark gray) as compared with those without sequence variations in the VWF coding sequence (light gray) for the entire type 1 VWD cohort by VWF:Ag as compared with the healthy controls. The percent of each group with sequence variations is shown at the top of each column. Sequence variations were most common in those with VWF:Ag <30.