Involvement of LAPTM5 and HCLS1 subnetworks in WM. (A) LAPTM5 and HCLS1 modules were retrieved from the HEFalMp database as being among the top 25 WM-associated genes. Genes shared between the 2 modules are shown in pink; those unique to the LAPTM5 module are in blue and HCLS1-unique genes are in green. (B) Gene-to-gene connectivities (quantified by Pearson correlation coefficients, PCC) in HDs for the LAPTM5 and HCLS1 combined module. (C) Combined LAPTM5 and HCLS1 subnetwork in HDs, with a stringent cutoff (PCC >0.9). LAPTM5 and HCLS1 are highlighted in red, and 2 other known WM-associated genes are in blue. (D) Gene-to-gene connectivities in WM for the combined module. (E) Combined LAPTM5 and HCLS1 subnetwork in WM, with a less stringent cutoff (PCC > 0.8). (F) Ten thousand random subnetworks with the same size were sampled from WM and HD as background, and the distribution of mean connectivities was plotted as indicated; the observed change of mean connectivity in WM and HD was then compared with the background. P value is indicated.