Figure 4
![Figure 4. HCLS1g496a/D166N germ line variant characterizes familial WM cases. (A) Distribution of the variant among familial (n = 50) and nonfamilial (n = 196) cases. (B) Genomic structure: location of the HCLS1 locus is shown by a red line; the centromere is indicated by red triangles. Gene structure is also shown (National Center for Biotechnology Information Reference [RefSeq] number, NM_005335). The exon is indicated by a blue box. The variant localizes in exon 7. (C) Secondary structures for HCLS1 were predicted by Interpro (http://www.ebi.ac.uk/interpro). Mutation positions and amino acid changes are indicated in red.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/127/21/10.1182_blood-2015-11-680199/4/2598f4.jpeg?Expires=1724234211&Signature=Yvan~V2itptq9t4vM6X~DRXJtR0qr2wW2Ux7w-FyPzpaxTNobS6lmXuxC5OR8Cgao9eLQbH1ShItCYNNEAW4CIXWz8JdPjrkn6WVBIcO~z90o2rMQY9I4NP1GrqY1SXEu4ULypvUM1Qj554QC3V3ZEUjBfdi4q2yaDn6EJFX~6RbPYKh8yOOfqxj9gLkYdzS3lYmiv3nCcgYT5wG1hO4JLiOzba3aG~aCQ4Qw3W2cSEmmMcAyc8RnupwOW9QH1aUtdbBAo37KhQP8ns8XeXQuvb9ajgjYr2LibAW4nZ7irms4C8eC0vmNPuVmdH9lBlerJD7kWtogQpgPLNGE9XQKg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
HCLS1g496a/D166N germ line variant characterizes familial WM cases. (A) Distribution of the variant among familial (n = 50) and nonfamilial (n = 196) cases. (B) Genomic structure: location of the HCLS1 locus is shown by a red line; the centromere is indicated by red triangles. Gene structure is also shown (National Center for Biotechnology Information Reference [RefSeq] number, NM_005335). The exon is indicated by a blue box. The variant localizes in exon 7. (C) Secondary structures for HCLS1 were predicted by Interpro (http://www.ebi.ac.uk/interpro). Mutation positions and amino acid changes are indicated in red.
