Family with documented coinheritance of WM. (A) Squares indicate male family members, circles indicate female family members, and slashes indicate a deceased family member. In the family we studied, 3 members were identified as affected with WM (II:1, III:1, III:2). Arrowhead indicates the proband (first member diagnosed with WM). *Sequenced samples. Age of diagnosis is indicated for the 3 affected members with WM. The sequenced unaffected member was aged 75 years at the time of sampling. Other diseases are specified for all the remaining members. (B) Workflow for selecting potential WM-associated variants. The number of variants identified in each step is shown. CA, cancer; dx, diagnosis; 1000G, 1000 Genomes; WT, wild-type.