Potential consequences of intrahepatic activation of coagulation following liver injury. Liver injury results in decryption of hepatocyte (and/or biliary epithelial cell) tissue factor which results in the generation of thrombin. Thrombin potentially activates both pro- and antifibrogenic pathways: (1) It generates fibrin, which in an α_Mβ₂-dependent manner binds leukocytes resulting in antifibrogenic effects.¹  (2) It activates stellate cells resulting in enhanced collagen production.⁶  (3) It generates fibrin in the sinusoidal space resulting in microischemia and progression of disease.⁷  Professional illustration by Patrick Lane, ScEYEnce Studios.