Molecular outcomes of genome editing. Multiple possible repair outcomes of (A) 1 or (B) 2 DSBs in the genome. Schematics of indels, gene insertion, and gene correction are shown. Solid gold lines, inserted bases; dashed red lines, deleted bases; solid dark blue boxes, gene cassettes. Outcomes depicted are not exhaustive, and other outcomes, such as insertion of a gene cassette via NHEJ, are possible.^78,79