Figure 1
![Normal ABL1 kinase plays a tumor suppressor role in BCR-ABL1–induced leukemogenesis. BCR-ABL1 Abl1−/− [−/−], BCR-ABL1 Abl1+/+ [+/+], and BCR-ABL1 Abl1−/− leukemia cells reconstituted with YFP-ABL1 [−/−(+)] were inoculated IV into NOD/SCID mice. Kaplan-Meier survival curve of mice injected with (A) 103 freshly transfected cells [(−/−) and (+/+): n = 8] and (B) 103 [(+/+): n = 6, (−/−) and (−/−)+: n = 12] or (C) 105 [(−/−): n = 13, (+/+) and (−/−)+: n = 12] 5-week-old tissue-cultured cells; n = number of mice per group.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/127/17/10.1182_blood-2015-11-681171/4/2131f1.jpeg?Expires=1720289747&Signature=pM-JnDDZkauKxQ0-MQ-xCY5iO10r7vyhBsshIPAMEIcfm2U5xKtykHaCQVQJl~HahUjl4ovNyxUhhDR4WdmnHSDIh4TahiUzVENZ59B6XVVoxPHXtLzpDhaKjljnxwgEUxVmq5A-34TpJo7iL1ghnvTex63RddKqUZwkOZ676G-HDRJN235TCGWn0AMfKrrOsFY~5on9tb9VGRYzjzs01H4o59Ihfx6SZeYV8DtC~rAynJVIX0NTG6KgLE0XJ985kJabKa-Ww-h2lIz859B5TcFEDVRDUxsUn7HqgNh57dFR-Qua7ELZHzDJEe0BCCPO5PirSzJxQqrVtOwli1wpFQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Normal ABL1 kinase plays a tumor suppressor role in BCR-ABL1–induced leukemogenesis. BCR-ABL1 Abl1−/− [−/−], BCR-ABL1 Abl1+/+ [+/+], and BCR-ABL1 Abl1−/− leukemia cells reconstituted with YFP-ABL1 [−/−(+)] were inoculated IV into NOD/SCID mice. Kaplan-Meier survival curve of mice injected with (A) 103 freshly transfected cells [(−/−) and (+/+): n = 8] and (B) 103 [(+/+): n = 6, (−/−) and (−/−)+: n = 12] or (C) 105 [(−/−): n = 13, (+/+) and (−/−)+: n = 12] 5-week-old tissue-cultured cells; n = number of mice per group.
