Treatment-emergent AEs (N = 66). (A) Serious treatment-emergent AEs included pyrexia, diarrhea, pneumonitis, dyspnea, pneumonia, febrile neutropenia, lung infection, sepsis, and hypoxia. Grade ≥3 events included fatigue, rash, diarrhea, pneumonitis, dyspnea, pneumonia, febrile neutropenia, lung infection, sepsis, and hypoxia. Time to onset of pneumonitis in each patient. (B) The onset of pneumonitis occurred after study day 50 in each patient. In 9 of the 12 patients, pneumonitis onset occurred between days 50 and 100. In 3 of the 12 patients, onset occurred between days 100 and 150. There was no relationship between dose level and pneumonitis onset. Computed tomography images of severe pneumonitis. (C) Representative computed tomography images from 2 patients who developed severe pneumonitis. Diffuse ground-glass opacities and interstitial infiltrates are demonstrated.