TTT according to gene aberrations. (A) Comparison of TTT among patients carrying ATM mutations without 11q deletion (blue line), 11q deletion (red line), and cases carrying a WT ATM gene (gray line) (P = .0014 for ATM mutations vs WT; P < .0001 for 11q deletion vs WT; P = .93 for ATM mutations vs 11q deletion). (B) Comparison of TTT among cases carrying isolated subclonal SF3B1 mutations (light blue line), clonal SF3B1 mutations (dark blue line), and cases carrying a WT SF3B1 gene (gray line) (P < .0001 for clonal mutations vs WT; P=.22 for subclonal mutations vs WT; P = .045 for clonal vs subclonal mutations). (C) Comparison of TTT among patients carrying subclonal NOTCH1 mutations (light blue line), clonal NOTCH1 mutations (dark blue line), or WT NOTCH1 gene sequence (gray line) (P < .0001 for clonal mutations vs WT; P=.0001 for subclonal mutations vs WT; P = .88 for clonal vs subclonal mutations). (D) Comparison of TTT among patients carrying the mutated (black line) or unmutated IGHV gene sequence (gray line) (P < .0001). (E) Comparison of TTT among patients diagnosed with Rai I-IV (orange line) or Rai 0 disease (gray line) (P < .0001). P, P values by Gray test.