Graphical representation of gene aberrations observed in the entire cohort. (A) CNA, IGHV status, and mutational status of the studied genes are represented. Each column represents an untreated CLL case carrying at least 1 mutation in any of the studied genes. Bar plot on the right represents the number of times at which each CNA and IGHV status was observed in all mutated cases. Blue bar plots refers to the number of cases carrying isolated subclonal mutations, only clonal mutations, or both regarding the mutational status of the studied genes. Cases carrying ATM definitely/likely pathogenic germ line variants are also shown. (B) Incidence of TP53, ATM, BIRC3, SF3B1, and NOTCH1 alterations classified regarding its clonal representation in the study cohort. Del, deletion; mut, mutation/s.