Therapeutic administration of KD025 decreases cGVHD pathology. B10.BR mice transplanted with B6 BM and T cells were treated with varying doses of KD025 or 0.4% methylcellulose from days 28 to 56. (A) Day 60 pulmonary function tests. (B) Pathology scores for lung, liver, colon, and spleen on day 60 for mice treated with 150 mg/kg KD025. (C) Representative images of Masson’s Trichrome stain (left) and total mouse immunoglobulin (right) in the lungs of mice on day 60 and (D) quantifications. *P < .05; **P < .01; ***P < .001; ****P < .0001. Error bars represent standard error of the mean (SEM); data from 4 separate experiments with n = 8 per group.