Figure 1
![Figure 1. Accumulation of monoallelic mutations in HLH-causing genes increases the risk to develop clinical manifestations of HLH. Control (black squares), Prf1−/− (open squares), Rab27a+/− Stx11+/− (AS, open gray circles), Rab27a+/− Prf1+/− (AP, gray squares), and Rab27a+/− Prf1+/− Stx11+/− mice (ASP, gray open squares) were infected with 200 PFU of LCMV-WE. (A) Survival, (B) body weight, and (C) body temperature are shown. Data (mean ± standard error of the mean [SEM]) are representative of 3 to 4 independent experiments with at least 3 mice in each group. *P < .05.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/127/17/10.1182_blood-2015-12-688960/4/2113f1.jpeg?Expires=1723162849&Signature=qG~lJFwBdnX~PJB-GKNS~PScTLAJp0VsZeldYdcGjGzKNZI-j4mb0tIYV6STJ7qRWsvYyqn8XCuX~q1c~DpyXOHymQnM1XFiTY8AN3672WkaN1iJ-irKiKt72V3HCIpaJIYWuzmQeb52z-fJVk5V7xrY9m5K4Qz-eb6NQOJQyvagPCx1EmUxtKwT4vTJ3w67TrZgWuPL9rowWhjnqH-T0PKuywev5Zn6zo68J6arE0D42VzkcvsjL3I-peZcPAg0D21IK6JEQiWw-1v0X9EE0fIZmplfYzd1DhBenm6cimnkZ76QzUqO6SROuEbzSxMRVHj32BspPxyDN2~S9zZ3Wg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Accumulation of monoallelic mutations in HLH-causing genes increases the risk to develop clinical manifestations of HLH. Control (black squares), Prf1−/− (open squares), Rab27a+/−Stx11+/− (AS, open gray circles), Rab27a+/−Prf1+/− (AP, gray squares), and Rab27a+/−Prf1+/−Stx11+/− mice (ASP, gray open squares) were infected with 200 PFU of LCMV-WE. (A) Survival, (B) body weight, and (C) body temperature are shown. Data (mean ± standard error of the mean [SEM]) are representative of 3 to 4 independent experiments with at least 3 mice in each group. *P < .05.
