An algorithmic approach to FL. (A) Approach to the patient with newly diagnosed FL. Patients with newly diagnosed, advanced-stage, grade 1-2 or grade 3a FL can be managed using the proposed algorithm. Patients with FL grade 3b are generally managed according to the principles for diffuse large B-cell lymphoma. (B) Approach to the patient with recurrent FL. Management decisions must be individualized and are dependent upon a number of factors including patient age, comorbidities, goals of therapy, number and types of prior therapies, and efficacy of prior therapies. AlloSCT, allogeneic stem cell transplantation; AutoSCT, autologous stem cell transplantation.