Clonal evolution from diagnosis to MRD clonal PCs. (A) Overview of CNAs and (B) CNN-LOH detected in clonal PCs from matched BM samples from 12 patients at diagnosis and during MRD monitoring. In A, copy number profile of patient-paired diagnostic and MRD clonal PCs for each patient are stacked, with the diagnostic sample shown on the top (green) and the MRD sample in the bottom (salmon). Sample pairs are indicated on the y-axis and chromosome location on the x-axis. Blue shading indicates the presence of copy number loss; red indicates copy number gain. In B, CNN-LOH detected in diagnostic (green) and MRD (salmon) clonal PCs are represented by pink bars.