cAlb accumulation in the extravascular space. (A) cAlb accumulation was measured by the relative fluorescence remaining 15 seconds after each activating light pulse for 200 seconds (n = 47, ± SEM). (B) cAlb accumulation was measured for eptifibatide-treated thrombi (white), and vehicle-treated thrombi (black) (vehicle n = 12, eptifibatide n = 11; ± SEM). (C) Representative pseudo-colored images of cAlb intensity 3 minutes postinjury in vehicle-treated (left) and eptifibatide-treated (right) mice. The vessel wall is indicated by the dashed white line and platelets are outlined in black. (D) cAlb accumulation for diYF and WT thrombi, (E) cangrelor-treated, (F) hirudin-treated, and (G) cangrelor/hirudin-treated vs vehicle-treated thrombi (all n values the same as previously reported for the respective data set).