ADP drives fully competent core formation and shell recruitment. (A) Quantification of average platelet area, and (B) peak P-selectin–positive area of vehicle (black) and cangrelor-treated (white) thrombi. (C) Average cAlb extravasation time course and (D) dot plot of relative cAlb extravasation at 200 seconds postinjury. (A-D) Vehicle n = 15, cangrelor n = 20; ± SEM). (E) The average platelet area, and (F) peak P-selectin–positive area for vehicle (black) and cangrelor plus hirudin-treated (white) thrombi (± SEM). (G) Time course of relative cAlb extravasation, and (H) dot plot of cAlb extravasation at 200 seconds postinjury. (E-H) Vehicle, black n = 13; cangrelor plus hirudin, white n = 15.