Combinatorial TF binding is associated with promoter-distal interacting genomic regions. (A) Bar chart showing the enrichment of the individual histone modification or TF-binding peaks overlapping with the significant interaction fragments (yellow) or background interactions (blue). (B) Bar chart showing the overlapping number of bound TFs with the genomic coordinates of the CHi-C interaction data (blue) and random genomic coordinates (red). Specific enrichment for the CHi-C interaction data can be seen when 3 or more TFs are bound. (C) Individual binding peaks for each TF were separated into promoter (“baits” for CHi-C experiment) or distal (promoter-interacting regions, not considered “bait”). Distinct distributions of the 29 factors can be seen throughout the genome.