PD responses after single subcutaneous injection of ACE910 with neutralization of the endogenous FVIII. The time courses of APTT (A-B) and peak height of TG (C-D) after single subcutaneous injection of placebo (black circle), 0.001 mg/kg (light blue diamond), 0.01 mg/kg (pink reverse triangle), 0.1 mg/kg (green square), 0.3 mg/kg (blue triangle), and 1 mg/kg (red circle) of ACE910 in Japanese (A,C) and white (B,D) healthy subjects measured with neutralization of endogenous FVIII are shown. TG was undetectable at baseline in the majority of subjects in each dose group. TG remained undetectable throughout the study period in the majority of subjects receiving placebo (data not shown). Results are presented as mean ± standard deviation. Data out of the quantification range were handled as missing in summary statistics calculation. Summary statistics were not calculated when TG was undetectable in the majority of subjects at a certain dose group and time point. One observed data point of TG was excluded because of being judged as an outlier, considering its unlikely time course and drug concentration dependency.