PD responses after single subcutaneous injection of ACE910 without neutralization of the endogenous FVIII. The time courses of APTT (A) and peak height of TG (B) after single subcutaneous injection of placebo (black circle), 0.001 mg/kg (light blue diamond), 0.01 mg/kg (pink reverse-triangle), 0.1 mg/kg (green square), 0.3 mg/kg (blue triangle), and 1 mg/kg (red circle) of ACE910 in Japanese healthy subjects measured without neutralization of endogenous FVIII are shown. Results are presented as mean ± standard deviation.