Plasma FIX and FX concentrations after single subcutaneous injection of ACE910. The time courses of plasma FIX (A) and FX (B) concentration after single subcutaneous injection of placebo (black circle), 0.001 mg/kg (light blue diamond), 0.01 mg/kg (pink reverse triangle), 0.1 mg/kg (green square), 0.3 mg/kg (blue triangle), and 1 mg/kg (red circle) of ACE910 in Japanese healthy subjects are shown. The concentrations of FIX and FX including their activated forms in plasma were determined. Results are presented as mean ± standard deviation.