Plasma ACE910 concentration after single subcutaneous injection of ACE910. The time courses of plasma ACE910 concentration after single subcutaneous injection of 0.01 mg/kg (pink reverse triangle), 0.1 mg/kg (green square), 0.3 mg/kg (blue triangle), and 1 mg/kg (red circle) of ACE910 in Japanese (A) and white (B) healthy subjects are shown. Plasma ACE910 concentration was below the lower limit of quantification in all subjects at a dose of 0.001 mg/kg. Results are presented as mean ± standard deviation. Data out of the quantification range were handled as missing in summary statistics calculation. Summary statistics were not calculated when a plasma ACE910 concentration was below the lower limit of quantification in the majority of subjects at a certain dose group and time point.