Successful autologous HSCT leads to a renewed and more diverse Treg TCR repertoire. (A) Patient with severe autoimmune disease pre- and postautologous HSCT. The pie charts show TCR β-chain sequencing results in Treg and non-Treg cells collected from a patient with severe autoimmune disease before and after autologous HSCT. N represents the number of different TCR sequences per sample and Di indicates diversity (0 = no diversity, 1 = maximal diversity). Changes in Di before and after HSCT are also shown in the graph. (B) Four healthy controls (HC). For comparison, TCR β-chain sequencing results in Treg cells from 4 HCs are shown in a similar fashion. The figure has been adapted from Figure 4 in the article by Delemarre et al that begins on page 91. Professional illustration by Patrick Lane, ScEYEnce Studios.