OS according to MDS subtypes and GATA2 mutational status. (A) OS in 426 children and adolescents consecutively diagnosed with primary MDS according to MDS subtypes and GATA2 mutational status. (B) Overall survival in 100 children and adolescents with monosomy 7 according to GATA2 mutational status. Adv. MDS, advanced MDS subtypes; n.s., not significant; N, patients under risk; E, events; GATA2^mut, mutation carriers; GATA2^WT, patients with wild-type status.