SEs activate and phosphorylate STAT3 in both malignant and nonmalignant T cells. (A) Representative flow cytometric analysis of CFSE-stained malignant (SeAx) and nonmalignant (MF1850) T-cell lines mono- and cocultured with either vehicle (PBS) or recombinant SEA (50 ng/mL) for 24 hours. All samples were stained for pY(705)-STAT3. “PBS + Malign.” signifies gated nonmalignant T cells cocultured with malignant T cells, and vice versa for “SEA + Non-malign.”