The FOXP1-S1PR2 axis in GCBs and its dysregulation in DLBCL. (A) The S1PR2/Gα13/ARFGEF1/Rho axis inhibits GCB migration and survival, resulting in their GC retention and growth control. (B) In FOXP1^high DLBCL cells, FOXP1 suppresses S1PR2 expression, resulting in the loss of this inhibitory axis. Illustration by L. Patrussi, University of Siena.