Sirolimus improves multilineage cytopenias in non-ALPS patients. Panels depict changes in (A) hemoglobin, (B) reticulocyte count, (C) platelet count, and (D) ANC. Each line represents a different patient’s cell count at each time point measured. The dotted line depicts normal thresholds for hemoglobin and platelets. ANC, absolute neutrophil count.