Sirolimus improves multilineage cytopenias in patients with ALPS. Panels depict changes in (A) hemoglobin, (B) reticulocyte count, (C) platelet count, and (D) ANC. All ALPS patients had multilineage cytopenias. Each line represents a different subject’s cell count at each time point measured. The dotted line depicts normal thresholds for hemoglobin and platelets. Although patients may have started below the normal threshold, all but one of the patients reached a CR across all cell lines measured. ANC, absolute neutrophil count.