Dysplasia in the myeloid lineage. Representative images of (A-B) Giemsa-stained PB smears and (C) H&E-stained BM sections obtained from wild-type recipients transplanted with Crebbp^+/− LSKs or unfractionated BM cells. (A) Hypersegmented granulocytes. (B) Pseudo-Pelger-Huet anomalies in bilobed cells most consistent with neutrophils. (C) Atypical localization of immature precursors (red dashed line; ie, clusters of myeloid precursors present in the intertrabecular area, rather than adjacent to trabeculae or surrounding endothelial cells as is the case in wild-type hematopoiesis). Magnification: ×60. Scale bars, 10 μm; scale bar provided in Biv serves all images included in A and B.