American Society of Hematology

Figure 3

$Figure 3. Dysplasia in the erythroid lineage. Representative images are of (A-C,Dii-Diii) Giemsa-stained BM touch preparations, (Di) H&E-stained bone sections, and (E-F) Giemsa-stained PB smears obtained from wild-type recipients transplanted with Crebbp+/− LSKs or unfractionated BM cells. (A) Erythroid precursors with abnormal nuclear contours (lobulation). (Bi-Biv) Binucleated erythroid precursors. (Bv) Coexistence of (1) a binucleated erythroid precursor and (2) an erythroid precursor with nuclear budding. (Ci-Ciii) Erythroid precursors with nuclear budding. (Di-Diii) Karyorrhexis in erythroid precursors. (E) Basophilic stippling in peripheral red blood cells. (F) Anisopoikilocytosis, (1) microcytes, (2) macrocytes, (3) target cells, (4) tear-drop cells, and (5) red blood cell fragments. Magnification: (A-E) ×60 and (F) ×20. Scale bars, 10 μm; scale bar provided in Diii serves all images included in A to D.$

Dysplasia in the erythroid lineage. Representative images are of (A-C,Dii-Diii) Giemsa-stained BM touch preparations, (Di) H&E-stained bone sections, and (E-F) Giemsa-stained PB smears obtained from wild-type recipients transplanted with Crebbp^+/− LSKs or unfractionated BM cells. (A) Erythroid precursors with abnormal nuclear contours (lobulation). (Bi-Biv) Binucleated erythroid precursors. (Bv) Coexistence of (1) a binucleated erythroid precursor and (2) an erythroid precursor with nuclear budding. (Ci-Ciii) Erythroid precursors with nuclear budding. (Di-Diii) Karyorrhexis in erythroid precursors. (E) Basophilic stippling in peripheral red blood cells. (F) Anisopoikilocytosis, (1) microcytes, (2) macrocytes, (3) target cells, (4) tear-drop cells, and (5) red blood cell fragments. Magnification: (A-E) ×60 and (F) ×20. Scale bars, 10 μm; scale bar provided in Diii serves all images included in A to D.

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