Survival of 230 patients with AL amyloidosis treated with CyBorD. After a median follow-up of living patients for 25 months, 94 patients (41%) died. (A) Overall survival (cumulative proportion survival at 3 years, 55%) and time to second-line therapy or death (median, 13 months). (B) Survival according to cardiac stage. Cardiac staging is based on NT-proBNP (cutoff, 332 ng/L) and cTnT (cutoff, 0.035 ng/mL), or cTnI (cutoff, 0.1 ng/mL), with stage I, II, and III patients having none, one, or two markers above the cutoff, respectively. Stage IIIa patients have NT-proBNP ≤8500 ng/L and stage IIIb patients have NT-proBNP >8500 ng/L. Stage I, II, IIIa, and IIIb patients were 41, 77, 67, and 45, respectively. There were no deaths among stage I patients. Cumulative proportion survival at 3 years was 52% in stage II, 55% in stage IIIa, and 19% in stage IIIb. Survival of stage II and stage IIIa subjects was significantly shorter than that of stage I patients (P < .001). There was no difference in survival of stage II and stage IIIa patients (P = .613). The median survival of stage IIIb patients was 7 months (P < .001 compared with stages I, II, and IIIa). (C) Survival of 118 cardiac stage II and IIIa patients according to hematologic response (3-month landmark). Cumulative proportion survival at 3 years was 84% in patients reaching at least VGPR, 67% in subjects attaining PR (P = .042 compared with ≥ VGPR), and 10% in nonresponders (P < .001 compared with PR). The median survival of nonresponders was 10 months. (D) Survival of 31 cardiac stage IIIb patients according to hematologic response (3-month landmark). Median survival was 26 months for responders and 6 months for nonresponders (P < .001). The small number of patients did not allow discrimination between response categories. NR, no response; PR, partial response.