Prothrombotic and proatherogenic LDL fractions and their products operate via platelet pattern recognition receptors, including LOX-1, leading to α_IIbβ₃ activation and platelet aggregation. JNK, c-Jun N-terminal kinase; oxLDL, oxidized LDL; PAR-1, protease-activated receptor 1; TLR9, Toll-like receptor 9.