Figure 3
Figure 3. Cord blood T cells are rapidly recruited to the tumor compared with peripheral blood T cells. (A) Contiguous tumor sections (×10) of the CB and PB groups stained with CD3 and CD20 immuno-histochemical stain. Higher numbers of tumor-infiltrating CD3+ T cells were seen in the CB group compared with the PB group. (B) Density of tumor-infiltrating T cells per square millimeter (shown as scatter dot plot with median and interquartile range) was significantly higher in the CB group than in the PB group. Importantly, as shown in C, a significantly lower CD4:CD8 ratio was observed in CB TILs compared with PB TILs, suggesting higher numbers of CD8+ T cells infiltrated the tumor in the CB group compared with the PB group.

Cord blood T cells are rapidly recruited to the tumor compared with peripheral blood T cells. (A) Contiguous tumor sections (×10) of the CB and PB groups stained with CD3 and CD20 immuno-histochemical stain. Higher numbers of tumor-infiltrating CD3+ T cells were seen in the CB group compared with the PB group. (B) Density of tumor-infiltrating T cells per square millimeter (shown as scatter dot plot with median and interquartile range) was significantly higher in the CB group than in the PB group. Importantly, as shown in C, a significantly lower CD4:CD8 ratio was observed in CB TILs compared with PB TILs, suggesting higher numbers of CD8+ T cells infiltrated the tumor in the CB group compared with the PB group.

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