American Society of Hematology

Figure 4

$Figure 4. Flow cytometric assessment of erythroid cell differentiation in SCD mice treated with RN-1. (A) Peripheral blood cells were stained with anti-mouse CD71 and Ter119 antibodies to assess the erythroid differentiation profiles of RBCs in RN-1–treated or untreated SCD mice. Stained cells were sorted into 3 stages (I, immature; II, maturing; III, mature).40 The numbers in each rectangle represent the fractional percentages of cells at that developmental stage. (B) Statistically significant differences between differentiation stages of erythroid cells are indicated in comparing RN-1–treated or untreated SCD mice; data are presented as mean ± SD, n = 4-6 mice per group (*P < .05; **P < .01).$

Flow cytometric assessment of erythroid cell differentiation in SCD mice treated with RN-1. (A) Peripheral blood cells were stained with anti-mouse CD71 and Ter119 antibodies to assess the erythroid differentiation profiles of RBCs in RN-1–treated or untreated SCD mice. Stained cells were sorted into 3 stages (I, immature; II, maturing; III, mature).⁴⁰ The numbers in each rectangle represent the fractional percentages of cells at that developmental stage. (B) Statistically significant differences between differentiation stages of erythroid cells are indicated in comparing RN-1–treated or untreated SCD mice; data are presented as mean ± SD, n = 4-6 mice per group (*P < .05; **P < .01).

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