Mutation profiles of patient tumors subjected to WGS. (A) Each patient is plotted with a unique color. The vertical bars indicate the number of predicted, somatic SNVs in a 5-Mb window. (B) Pie charts of functional categories of the predicted somatic SNVs. For each patient, the left pie chart depicts the proportion of somatic mutations in categories based on their genomic location, including intergenic, intronic, ncRNA, and exonic SNVs. The right chart shows the breakdown of different mutation types in coding regions, including upstream/downstream, UTR, nonsynonymous, synonymous, stop-gain SNVs, and SNVs located in splicing sites. Only SNVs not included in dbSNP (build 131) or the 1000 Genome Project (November 2010) are shown. ncRNA, noncoding RNA; UTR, untranslated region.