cdh5-silenced blastula transplant successfully differentiates into red cells. (A) Schematic representation of the blastula transplantation strategy. Injections of equal amounts of rhodamine and cdh5-MO into erythroid transgenic embryo, lcr:eGFP, followed by transplantation of cdh5-silenced blastula (donor) cells of transgenic embryo between high and dome stage into age-matched casper-recipient embryo (wild-type) to analyze whether donor cells can contribute to transgenic erythroid cells in a recipient embryo. (B) Transplantation of cdh5-silenced transgenic blastula reconstituted into lcr:eGFP⁺ erythroid cells into casper recipient embryos, indicating that the cell-intrinsic role of cdh5 is dispensable for blastula differentiation into erythroid cells (examples are demonstrated with arrows); n = 14 recipients.