Relapse-free survival and OS from CR according to the new risk classification of Beldjord et al. (A) Relapse-free survival in T-ALL patients (86% vs 52% at 5 years; hazard ratio [HR], 4.20; 95% CI, 1.85-9.51; P = .001). (B) OS from CR in T-ALL patients (91% vs 62% at 5 years; HR, 4.14; 95% CI, 1.58-10.83; P = .004). High risk includes MRD-positive and or adverse genetics including no NOTCH1/FBXW7 mutation or presence of N/K-RAS mutation and/or PTEN gene alteration.