Microarray analysis of gene profile altered within PF-2341066–treated PEL cell lines. (A) The HumanHT-12 v4 Expression BeadChip (Illumina) was used to detect gene profile altered within PF-2341066–treated PEL cell lines (BCBL-1, BC-1, and BCP-1) when compared with vehicle-treated control. Intersection analysis of significantly altered genes (up/down at least twofold and P < .05) was performed using Illumina GenomeStudio software. Set I: Common genes altered in all the 3 cell lines. Set II: Similar genes altered in every 2 cell lines. Set III: Unique genes altered in each cell line. (B-C) The transcriptional levels of selected 4 candidate genes downregulated (B) or upregulated (C) as shown in microarray data were validated by using qRT-PCR, respectively. Error bars represent the S.E.M. for 3 independent experiments. (D-F) The enrichment analysis of gene profile (common, similar, and unique set as indicated) significantly altered by c-MET inhibitor was performed using the MetaCore software (Thompson Reuters) modules: Pathway Maps (D), Gene Ontology Processes (E), and Process Networks (F).