Activation of mTOR signaling in TCL cell lines (n = 6) and normal T cells (n = 3). Western blotting was performed on 6 TCL cell lines of ALCL (Karpas 299, SUDHL1, and SR786) and CTCL (HuT 78, SeAx, and MyLa) subtypes, along with CD3⁺ T cells using phosphorylation site-specific antibodies for mTOR, AKT, and 4EBP1.