The process to generate CAR-modified T cells. Patients undergo steady-state leukapheresis for T-cell collection. Lentiviral vector is used to infect the T cells and transfer the new genetic material encoding the CAR. Modified cells undergo short-term culture for expansion and activation, and after 12 to 14 days are harvested for infusion. Patients typically receive lymphodepleting chemotherapy prior to T-cell infusion.