Activated Kcc1 cotransporter promotes end-organ damage in sickle cell disease. Histologic sections of lung, kidney, and liver stained with hematoxylin and eosin. Tissues were harvested from 10-week-old wild-type mice (AA^+/+), sickle homozygous mice (SS^+/+), and sickle homozygous with heterozygous Kcc1 mutation (SS^+/M935K). Sections are representative of 3 mice of each genotype.