Platelet response, Kaplan Meier analyses and CD4⁺ lymphocyte depletion. (A) Whisker plots of platelet counts during the first 12 months from responders. The central horizontal bold line is the median; the cross is the mean; the lower and upper box limits are the first and third quartiles, respectively; and the whiskers include all data points. One patient relapsed at month 7. (B) Kaplan-Meier analysis of all patients treated with TT4. Vertical marks indicate the last follow-up of an ongoing response; 47% of the 20 treated patients were estimated to have a long-term response of >46 months from treatment. (C) Kaplan-Meier TFS curve for all patients. Median undefined, 75% treatment free at 12 months (95% CI, 49-88%). (D) Whisker plots of CD4⁺ T cells during the first 7 months: responders vs nonresponders. Median 0.62 vs 0.91 (P < .0001). The central horizontal line is the median; the lower and upper box limits are the first and third quartiles, respectively; and the whiskers include all data points. CD4⁺ counts were not significantly lower in men compared with women (P = .1639).