Intact platelet function in RIAM^−/− mice. (A) Light transmission aggregometry of washed platelets obtained from heparinized whole blood of control or RIAM^−/− mice after stimulation with low-dose (LD) or high-dose (HD) Par4p (50 or 100 µM) or convulxin (75 or 150 ng/mL). Four pairs of mice were studied, and representative curves are shown. (B) Real-time activation of the αIIbβ3 integrin after stimulation with Par4p or convulxin was measured in washed platelets using JON/A-PE. Combined data from 4 pairs of mice are shown.