Figure 7
Inhibition of TNTs sensitizes BCP-ALL cells to prednisolone. (A) Leukemic cell survival of patient ALL#6 cells cultured with or without MSCs after 5 days of prednisolone exposure (0.3 µg/mL). All graphs show percentage compared with untreated control. TNT signaling was inhibited by shaking or transwell conditions (1-tailed t test, unpaired). Quadruplicates represent 4 different sources of MSCs (MSC#1, MSC#2, MSC#6, MSC#7). (B) Leukemic cell survival of BCP-ALL cell line NALM6 cultured with or without MSCs after 5 days of prednisolone exposure. All graphs show percentage compared with untreated control. TNT signaling was inhibited by shaking or transwell conditions (1-tailed t test, unpaired). Triplicates represent 3 different sources of MSCs (hTERT, MSC#1, and MSC#2). Data are means ± SEM; *P ≤ .05, **P ≤ .01 (see also supplemental Figure 10).

Inhibition of TNTs sensitizes BCP-ALL cells to prednisolone. (A) Leukemic cell survival of patient ALL#6 cells cultured with or without MSCs after 5 days of prednisolone exposure (0.3 µg/mL). All graphs show percentage compared with untreated control. TNT signaling was inhibited by shaking or transwell conditions (1-tailed t test, unpaired). Quadruplicates represent 4 different sources of MSCs (MSC#1, MSC#2, MSC#6, MSC#7). (B) Leukemic cell survival of BCP-ALL cell line NALM6 cultured with or without MSCs after 5 days of prednisolone exposure. All graphs show percentage compared with untreated control. TNT signaling was inhibited by shaking or transwell conditions (1-tailed t test, unpaired). Triplicates represent 3 different sources of MSCs (hTERT, MSC#1, and MSC#2). Data are means ± SEM; *P ≤ .05, **P ≤ .01 (see also supplemental Figure 10).

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