Structural impact of CHD2 mutations in CLL and MBL. (A) Schematic representation of CHD2 structure and distribution of the mutations identified in the cohorts of CLL (n = 456) and MBL (n = 43). Red arrows indicate frameshift mutations, splice site alterations, and premature stop codons; whereas black arrows represent single nucleotide variants (SNVs) and a single residue deletion. CHROMO, chromatin organization modifier domain; DEXDc, Dead-like helicase superfamily; DUF4208, domain of unknown function 4208; HELICc, helicase superfamily c-terminal. (B) Amino acid sequence alignments of the regions surrounding the identified SNVs show the high phylogenetic conservation of the affected residues.