Regulatory networks in early B-cell development. Schematic drawing over regulatory networks involved in B-cell priming, specification, and commitment. Specific stages and loss of lineage potentials are indicated. Green arrows indicate activation of transcription and red repression of transcription. B, B lymphocyte; CLP, common lymphoid progenitor; G/M, granulocyte/monocyte; LMPP, lymphoid-primed multipotent progenitor; Mk/E, megakaryocyte/erythroid; MPP, multipotent progenitor; NK/DC, natural killer/dendritic; T, T lymphocyte.